Mathilde Carpentier

FlavoTyper is a genome-based in-silico tool for serotyping Flavobacterium psychrophilum, showing strong association between O-types and host fish species.

The paper uses a mechanistic model to show that structural divergence in enzymes varies due to mutation, stability, and activity constraints, with different contributions across enzyme families.

The paper shows that structural divergence in enzymes correlates with residue flexibility and distance from the active site, arising from non-functional and functional evolutionary constraints.

The paper evaluates sequence- and structure-based multiple alignment programs using reference databases, finding structure-based methods perform better at low sequence identity and for structured residues.