The paper identifies a conserved long non-coding RNA in Leishmania braziliensis and shows its structural importance for parasite fitness and RNA-protein interactions.

DOI 10.1101/2025.01.14.632970

statistical model

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMay 25, 2024

A short noncoding RNA modulates gene expression and affects stress response and parasite differentiation in Leishmania braziliensis

José Carlos Quilles Junior, Caroline Ricce Espada, Lissur Azevedo Orsine…·Ângela K. Cruz

This study identifies and functionally characterizes a noncoding RNA in Leishmania braziliensis that influences stress response and parasite differentiation.

1 citation

experimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintSep 15, 2023

Leishmania Ribosomal Protein (RP) paralogous genes compensate each others expression maintaining protein native levels

Francisca S. Borges, José Carlos Quilles Junior, Lucas B. Lorenzon…·Ângela K. Cruz

The paper investigates compensatory expression of Leishmania ribosomal protein paralogs, showing protein-level compensation without transcript-level changes.

DOI 10.1101/2023.09.15.557908

experimental assay

𝕏 PostBluesky

Molecular BiologyACS Infectious DiseasesPeer-reviewedFeb 28, 2022

Functional study of Leishmania braziliensis protein arginine methyltransferases (PRMTs) reveals that PRMT1 and PRMT5 are required for macrophage infection

Lucas B. Lorenzon, José Carlos Quilles Junior, Gustavo D. Campagnaro…·Ângela K. Cruz

This study functionally characterizes PRMTs in Leishmania braziliensis, showing PRMT1 and PRMT5 are required for macrophage infection and axenic amastigote proliferation.

19 citations

experimental assay

𝕏 PostBluesky