Joshua E. Berlind

This paper introduces BOB-seq, a method for isoform-resolved multiplexed RNA sequencing that uses bioorthogonal barcoding to capture full-length transcripts and improve splicing effect detection.

This study uses high-intensity focused ultrasound to induce traumatic brain injury in human iPSC-derived cortical organoids, revealing key pathological features like tau phosphorylation and neurodegeneration.

This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.