Author

Zhiwen Zhong

King's College LondonORCID 0000-0001-8950-6371Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Approach:statistical model· 1

Frequent Co-Authors

Christian D. LorenziD· 2 shared Martin B. UlmschneideriD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

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2 shared papersBiophysics

Christian D. LorenzORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintJun 26, 2025

Structural Impact of Alzheimer's Disease Mutations on Transmembrane TREM2-DAP12 Interactions: An Atomistic Perspective

Zhiwen Zhong, Martin B. Ulmschneider, Christian D. Lorenz

This study uses molecular dynamics simulations to analyze how TREM2 mutations affect the stability of the TREM2-DAP12 complex, revealing structural impacts on neuroimmune signaling in Alzheimer's disease.

DOI 10.1101/2025.06.26.661739

humanstructural biology

𝕏 PostBluesky

BiophysicsACS OmegaPeer-reviewedJun 21, 2024

Understanding the binding mechanisms of Alzheimer risk factor TREM2 in lipid bilayer using multi-scale molecular dynamics simulations

Zhiwen Zhong, Martin B. Ulmschneider, Christian D. Lorenz

This paper uses multi-scale molecular dynamics simulations to study the TREM2/DAP12 transmembrane domain complex formation and its role in Alzheimer's disease.

8 citations

structural biologydeep learning

𝕏 PostBluesky