GeneticsbioRxivPreprint
Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function
Anne Raimondo, Søren Krogsgaard Thomsen, Benoît Hastoy…·Anna L. Gloyn
This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.
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