Author
University of AlbertaORCID 0000-0002-4157-2094Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Mariya Mardamshina, Nicolai Dorka, Marvin Thielert…·Emma K. Lundberg
This paper introduces mxDVP, a method combining high-plex imaging and mass spectrometry to profile pancreatic islets, identifying 12 endocrine subtypes and revealing spatial heterogeneity and rare cell states.
Theodore dos Santos, Xiao Qing Dai, Robert C. Jones…·Patrick E. MacDonald
This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.
Hannah M Mummey, Weston S. Elison, Katha Korgaonkar…·Kyle J. Gaulton
The paper uses single-cell multiome profiling to identify gene regulatory changes in pancreatic islets linked to diabetes risk factors like age, sex, and genetic variants.
Jessica Ewald, Yao Lu, Cara E. Ellis…·Patrick E. MacDonald
HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.
Antje K. Rottner, Yingying Ye, Elena Navarro‐Guerrero…·Anna L. Gloyn
A genome-wide CRISPR screen in human pancreatic beta cells identifies 580 genes influencing insulin content, supporting 20 candidate type 2 diabetes effector transcripts.
Ana Viñuela, Arushi Varshney, Martijn van de Bunt…·Mark I. McCarthy
The paper investigates how genetic variants affect gene expression in human pancreatic islets and identifies candidate genes linked to type 2 diabetes.
Anne Raimondo, Søren Krogsgaard Thomsen, Benoît Hastoy…·Anna L. Gloyn
This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.