Austin Bautista

Linking molecular pathways and islet cell dysfunction in human type 1 diabetes

This study investigates islet cell dysfunction in type 1 diabetes by integrating electrophysiological, transcriptomic, and machine learning analyses of human islet cells from T1D donors.

Cisplatin exposure dysregulates pancreatic islet function in male mice

This study shows cisplatin exposure impairs pancreatic islet function in male mice by disrupting insulin secretion and causing DNA damage in beta cells.

Human research islet cell culture outcomes at the Alberta Diabetes Institute IsletCore

The paper examines islet isolation and culture outcomes at the Alberta Diabetes Institute IsletCore, finding islet loss occurs within 24 hours of isolation with no further loss after extended culture.

HumanIslets: An integrated platform for human islet data access and analysis

HumanIslets.com provides an open platform for accessing and analyzing human islet data, enabling research on diabetes through integrated molecular and cellular phenotyping.

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk

A genome-wide CRISPR screen in human pancreatic beta cells identifies 580 genes influencing insulin content, supporting 20 candidate type 2 diabetes effector transcripts.

Pancreas patch-seq links physiologic dysfunction in diabetes to single-cell transcriptomic phenotypes

This study links transcriptomic heterogeneity in pancreatic islet cells to their physiological function using a combined electrophysiological and single-cell RNA sequencing approach, identifying genes and pathways associated with diabetes-related dysfunction.

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.