Author

Søren Krogsgaard Thomsen

University of OxfordORCID 0000-0001-8894-2868Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Anna L. GloyniD· 3 shared Austin Bautista· 2 shared Benoît HastoyiD· 2 shared Jocelyn E. Manning FoxiD· 2 shared Nicola L. BeeriD· 2 shared Patrick E. MacDonaldiD· 2 shared Patrik RorsmaniD· 2 shared Agata Wesolowska‐AnderseniD· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersGenetics

Anna L. GloynORCID

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3 papers

Recent·Most cited

GenomicsNature GeneticsPeer-reviewedDec 21, 2022

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk

Antje K. Rottner, Yingying Ye, Elena Navarro‐Guerrero…·Anna L. Gloyn

A genome-wide CRISPR screen in human pancreatic beta cells identifies 580 genes influencing insulin content, supporting 20 candidate type 2 diabetes effector transcripts.

63 citationstop 1%

humanCRISPR screen

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GeneticsNature GeneticsPeer-reviewedNov 1, 2019

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Om Prakash Dwivedi, Mikko Lehtovirta, Benoît Hastoy…·Leif Groop

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

144 citationstop 1%

humanexperimental assay

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GeneticsbioRxivPreprintJul 3, 2017

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

Anne Raimondo, Søren Krogsgaard Thomsen, Benoît Hastoy…·Anna L. Gloyn

This study identifies T2D risk alleles in PAM that impair beta cell function through distinct effects on expression and catalytic activity, revealing a novel mechanism involving Chromogranin A.

3 citations

humanbulk RNA-seq

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