David M. McKean

This study integrates public transcriptomic data with network analysis to identify molecular features of psoriasis, revealing key genes and networks involved in the disease.

This paper develops a Bayesian method to detect copy number variants and assess their association with disease in large-scale studies, finding deletions near MYC and TUSC3 linked to pancreatic cancer.

The paper identifies mosaic mutations in blood and cardiac tissue from CHD patients, finding 1% of cases have detectable mosaic variants that may contribute to congenital heart disease.