Paul Aiyetan

The paper investigates synthetic lethality in vorinostat-resistant HCT116 colon cancer cells, finding that resistance is linked to rewiring of oncogenic pathways rather than embryonal gene regulation.

jFuzzyMachine is a fuzzy logic-based regulatory network inference tool that identifies more regulatory edges than ARACNe and provides interaction directionality in high-throughput biological data.

The paper introduces a multistaged-hyperparallel optimization method to accelerate fuzzy logic regulatory model inference, reducing computation time from 485.6 hours to 9.6 hours for a molecular regulation problem.

MS-PyCloud is an open-source cloud-based pipeline for LC-MS/MS data analysis that provides scalable, reproducible, and efficient processing of proteomics data.