Doğa Cedden

This study identifies insecticidal dsRNAs targeting the proteasome pathway in the hop flea beetle using dsRIP and demonstrates their efficacy in bioassays.

The paper profiles RISC-bound siRNAs from insect larvae to understand guide strand selection and siRNA modifications, identifying sequence features that influence strand bias and terminal modifications.

This study shows orally ingested dsRNA reaches the CNS of Leptinotarsa decemlineata and is processed into siRNAs, providing evidence of systemic RNAi transport in this pest.

This study identifies proteomic changes during aestivation in cabbage stem flea beetles, finding reduced translation proteins and proteolysis-related proteins at termination, with discrepancies compared to RNA-seq results.

This study identifies sequence features for effective dsRNA in insect pest control and develops a web-platform to optimize dsRNA design for RNAi.

This study identifies the reciprocal roles of two trehalose transporters, Tret-1 and Tret-2, in regulating trehalose dynamics and metabolic stability during aestivation in cabbage stem flea beetles.

This paper investigates dsProsβ1-mediated proteasome targeting in the cabbage stem flea beetle using RNA degradomics and proteomics to reveal molecular mechanisms of RNAi-based pest control.

This study shows that the miRNA pathway regulates obligatory aestivation in the cabbage stem flea beetle by controlling metabolism, catabolism, and resilience to high temperatures.

This study investigates physiological and transcriptional changes in the cabbage stem flea beetle during aestivation, finding reduced carbohydrate reserves, increased lipid reserves, and differential expression of metabolism-related genes.

This study identifies highly effective target genes for RNA interference-based control of the cabbage stem flea beetle, showing 100% mortality and reduced leaf damage with dsRNA.

The paper identifies superior target genes and pathways for RNAi-based pest control in the red flour beetle using genome-wide analysis and validates effective targets for oral application in other pests.