BioinformaticsbioRxivPreprint
Accuracy of a machine learning method based on structural and locational information from AlphaFold2 for predicting the pathogenicity of TARDBP and FUS gene variants in ALS
Yuya Hatano, Tomohiko Ishihara, Osamu Onodera
The paper develops MOVA, a machine learning method using AlphaFold2 structural data to predict pathogenicity of ALS-related gene variants, showing good accuracy for TARDBP and FUS.
DOI 10.1101/2022.07.07.499092