Osamu Onodera

The paper identifies exitron-type splicing events in IDR-coding sequences across jawed vertebrates, showing donor-proximal cis control in TARDBP despite sequence divergence.

This study shows that export-biased TDP-43 with intact 3' UTR leads to cytoplasmic aggregation and splicing defects, even when exogenous levels match endogenous, suggesting loss of nuclear function.

This paper shows that enhancing TARDBP exitron splicing reduces TDP-43 aggregation and neurodegeneration in disease models using ASOs.

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

This study shows FUS suppresses RAN translation by modulating G-quadruplex structure of GGGGCC repeat RNA, reducing neurodegeneration in C9-ALS/FTD model flies.

The paper develops MOVA, a machine learning method using AlphaFold2 structural data to predict pathogenicity of ALS-related gene variants, showing good accuracy for TARDBP and FUS.

The paper shows that age-related DNA demethylation in the TARDBP 3'UTR reduces alternative splicing and increases TARDBP mRNA expression in the human motor cortex, linking this to earlier ALS onset.

This study shows that ectopic expression of human tau in mice leads to abnormal somatodendritic distribution, while knock-in mice show normal axonal localization due to developmental expression patterns.