Interactions with lipid membrane modulate the conformational dynamics and energy landscape of Tumor Necrosis Factor
George Khelashvili, István Kolossváry, Woody Sherman, Fabio Trovato
This study investigates how lipid membrane interactions affect the conformational dynamics and energy landscape of membrane-bound TNF, showing that membrane association stabilizes the symmetric state over asymmetric conformations.
bioRxiv · Nov 28, 2025 · PreprintBiophysics