George Khelashvili

Interactions with lipid membrane modulate the conformational dynamics and energy landscape of Tumor Necrosis Factor

This study investigates how lipid membrane interactions affect the conformational dynamics and energy landscape of membrane-bound TNF, showing that membrane association stabilizes the symmetric state over asymmetric conformations.

Structural Diversity and Dynamics of Metabotropic Glutamate Receptor/Beta-Arrestin Coupling

This study investigates the structural and dynamic diversity of metabotropic glutamate receptor/beta-arrestin coupling using biophysical and structural methods, revealing new coupling stoichiometries and interaction mechanisms.

How structural elements added by evolution from bacterial transporters to human SLC6 homologs have enabled new functional properties

This study investigates how structural elements in human SLC6 transporters, evolved from bacterial homologs, enable new functional properties like reverse uptake through molecular dynamics and Markov State Model analysis of hDAT.