Sergey Kryazhimskiy

Module-selection balance in the evolution of modular organisms

This study investigates how modular genotype-phenotype-fitness maps constrain trait evolution, showing that modular systems reach a module-selection balance where traits improve at the same rate.

Putting BASIL in a BLT: A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations

This paper introduces BASIL, a Bayesian method to estimate fitness effects of beneficial mutations from BLT data, showing it is more accurate and robust than existing methods.

Improved Genotype Inference Reveals Cis- and Trans-Driven Variation in the Loss-of-Heterozygosity Rates in Yeast

The paper improves genotype inference in yeast to reveal that LOH rates vary due to trans and cis factors, challenging previous findings.

Environment-independent distribution of mutational effects emerges from microscopic epistasis

The paper shows that mutational effects on microbial growth rate follow a pattern of global epistasis that is invariant across environments.

Emergence and Propagation of Epistasis in Metabolic Networks

The paper derives rules for how epistasis propagates through hierarchical metabolic networks and shows that weak epistasis can be distorted at higher levels.