Author

Alena Martsul

University of California San DiegoORCID 0000-0001-6781-826XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:yeast· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Sergey KryazhimskiyiD· 2 shared Justin R. MeyeriD· 1 shared Krypton CarolinoiD· 1 shared Michael S. OvertoniD· 1 shared Milo S. JohnsoniD· 1 shared Omar S. AkbariiD· 1 shared Sarah M. ArdelliD· 1 shared Sean E. Guy· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersEvolutionary Biology

Sergey KryazhimskiyORCID

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2 papers

Recent·Most cited

Evolutionary BiologyG3 Genes Genomes GeneticsPeer-reviewedFeb 18, 2026

Experimental Test of Evolutionary Safety of a CRISPR-Cas9 Gene-Drive Element

Michael S. Overton, Sean E. Guy, Xingsen Chen…·Sergey Kryazhimskiy

The paper tests the evolutionary safety of CRISPR-Cas9 gene drives in yeast by measuring their impact on mutation rates and loss-of-heterozygosity, finding minimal effects.

5 citations

yeastexperimental assay

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Systems BiologySciencePeer-reviewedOct 3, 2024

Environment-independent distribution of mutational effects emerges from microscopic epistasis

Sarah M. Ardell, Alena Martsul, Milo S. Johnson, Sergey Kryazhimskiy

The paper shows that mutational effects on microbial growth rate follow a pattern of global epistasis that is invariant across environments.

35 citationstop 1%

yeaststatistical model

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