Author

Charlotte Janssens

Vrije Universiteit BrusselORCID 0000-0001-9250-852XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

Anfien HuyghebaertiD· 3 shared Claudia SpitsiD· 3 shared Yingnan LeiiD· 3 shared Diana Al DelbanyiD· 2 shared Edouard Couvreu de DeckersbergiD· 2 shared Karen SermoniD· 2 shared Mai Chi DuongiD· 2 shared Marius ReginiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersDevelopmental Biology

Anfien HuyghebaertORCID

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3 papers

Recent·Most cited

Developmental BiologybioRxivPreprintMar 29, 2026

Increases in BCL2L1 and ID1 dosage synergistically drive fate bias and competitive advantage in human pluripotent stem cells

Yingnan Lei, Nuša Krivec, Arkajyoti Sarkar…·Claudia Spits

This study shows that increased BCL2L1 and ID1 gene dosage in human pluripotent stem cells drives competitive advantage and fate bias toward non-neural ectodermal and extraembryonic fates during differentiation.

1 citation

humanscRNA-seq

𝕏 PostBluesky

Cell BiologyCell ProliferationPeer-reviewedFeb 5, 2025

Loss of 18q alters TGFβ signalling affecting anteroposterior neuroectodermal fate in human embryonic stem cells

Yingnan Lei, Mai Chi Duong, Nuša Krivec…·Claudia Spits

This study shows that loss of chromosome 18q in hESCs impairs differentiation into retinal progenitor cells by disrupting TGFβ signaling and anteroposterior neuroectodermal fate commitment.

4 citations

humanscRNA-seq

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Developmental BiologyeLifePeer-reviewedDec 9, 2024

Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos

Marius Regin, Yingnan Lei, Edouard Couvreu de Deckersberg…·Claudia Spits

The paper investigates the cellular consequences of aneuploidy in human blastocysts, finding p53-mediated apoptosis and impaired lineage segregation.

8 citations

humanbulk RNA-seq

𝕏 PostBluesky