Author

Edouard Couvreu de Deckersberg

Vrije Universiteit BrusselORCID 0000-0002-1199-4536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Claudia SpitsiD· 4 shared Karen SermoniD· 4 shared H. Van de VeldeiD· 3 shared Marius ReginiD· 3 shared Anfien HuyghebaertiD· 2 shared Charlotte JanssensiD· 2 shared Christophe BlockeeliD· 2 shared Florence BelvaiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersCell Biology

Claudia SpitsORCID

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4 papers

Recent·Most cited

Cell BiologyCell ProliferationPeer-reviewedFeb 5, 2025

Loss of 18q alters TGFβ signalling affecting anteroposterior neuroectodermal fate in human embryonic stem cells

Yingnan Lei, Mai Chi Duong, Nuša Krivec…·Claudia Spits

This study shows that loss of chromosome 18q in hESCs impairs differentiation into retinal progenitor cells by disrupting TGFβ signaling and anteroposterior neuroectodermal fate commitment.

4 citations

humanscRNA-seq

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Developmental BiologyeLifePeer-reviewedDec 9, 2024

Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos

Marius Regin, Yingnan Lei, Edouard Couvreu de Deckersberg…·Claudia Spits

The paper investigates the cellular consequences of aneuploidy in human blastocysts, finding p53-mediated apoptosis and impaired lineage segregation.

8 citations

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintSep 5, 2022

Differences in maternally inherited and age-related de novo mitochondrial DNA variants between ART and spontaneously conceived individuals associate with low birth weight

Joke Mertens, Florence Belva, Aafke P.A. van Montfoort…·Claudia Spits

The paper identifies mtDNA variants in ART and spontaneously conceived individuals linked to lower birth weight, showing sex-dependent effects and maternal aging influences.

DOI 10.1101/2022.09.05.22279608

humanwhole-genome sequencing

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GeneticsHuman Molecular GeneticsPeer-reviewedMar 8, 2022

Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally

Joke Mertens, Marius Regin, Neelke De Munck…·Claudia Spits

The paper shows that mtDNA mosaicism arises early in human preimplantation development and persists into adulthood through asymmetric mitochondrial distribution.

14 citations

humanwhole-genome sequencing

𝕏 PostBluesky