BiophysicsScientific ReportsPeer-reviewed
Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity
Amanat Ali, Zhengdong D. Zhang, Tina Gao…·Sofiya Milman
This study identifies two functional IGF-1 coding variants in centenarians that may contribute to exceptional longevity by impairing IGF-1R activity and reducing circulating IGF-1 levels.
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