Evripidis Gavathiotis

Binding kinetics enable tumor-selective MAPK and growth suppression by a Type 1 RAF Inhibitor

This study identifies ELV-3111, a Type 1 RAF inhibitor that selectively suppresses MAPK and tumor growth by exploiting distinct binding kinetics, showing efficacy in RAS-mutant and BRAF-mutant models.

Spatial modulation of RAF by RAF/MEK glue enables full-dose combination with pan-RAF inhibitor and potent RAS-mutant tumor-selective MAPK and growth inhibition

The paper shows RAF/MEK glues enable full-dose combination with pan-RAF inhibitors, enhancing tumor-selective MAPK inhibition and tumor regression in RAS-mutant models.

The GNMT N-terminus Couples Folate Feedback to Methyl-donor Homeostasis

This study identifies the GNMT N-terminal tail and its phosphorylation at S9 as a regulatory mechanism linking folate feedback to SAM homeostasis.

A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia

This paper shows that targeting STAT3 with a degrader can overcome Venetoclax resistance in AML by reducing MCL1 and improving mitochondrial function.

Quiescent OXPHOS-high triple-negative breast cancer cells that persist after chemotherapy depend on BCL-XL for survival

This study identifies OXPHOS-high quiescent triple-negative breast cancer cells that survive chemotherapy and depend on BCL-XL for survival, showing that targeting BCL-XL enhances chemotherapy efficacy.

Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity

This study identifies two functional IGF-1 coding variants in centenarians that may contribute to exceptional longevity by impairing IGF-1R activity and reducing circulating IGF-1 levels.

RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors

This study evaluates the signaling inhibition index (SII) of various RAS-targeted inhibitors across RAS-mutant and wild-type models, revealing significant variability in their effectiveness and selectivity.

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

This study combines APOE4 and TREM2R47H in female tauopathy mice to identify pathways activated by AD risk factors, finding cGAS-STING signaling and microglial senescence as potential drivers.

Direct Small Molecule Activation of Mitofusins

This study identifies MASM7 as a direct activator of mitofusin 2, promoting mitochondrial fusion through conformational changes.