Author

Eric D. Sakkas

Wesleyan UniversityORCID 0000-0001-9283-3306Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:CUT&Tag· 1 Research Focus:differential expression· 1 Assay:Hi-C· 1

Frequent Co-Authors

Daniel Krizanc· 2 shared Kelly M. ThayeriD· 2 shared Michael P. WeiriD· 2 shared Ana C. Onuchic-WhitfordiD· 1 shared Anya GreenbergiD· 1 shared Audrey E. McMahon· 1 shared Christopher Lund O'ConnoriD· 1 shared Dongwon LeeiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Daniel Krizanc

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3 papers

Recent·Most cited

The landscape of allele-specific expression in human kidneys

Ana C. Onuchic-Whitford, Junmo Sung, Eric D. Sakkas, Michelle T. McNulty, Victoria Mezger, Christopher Lund O'Connor, Anya Greenberg, Jihoon G. Yoon, Sowmya Badina, Laura H. Mariani, Markus Bitzer, Matthew Gordon Sampson, Dongwon Lee

This study maps allele-specific expression in human kidney disease, finding increased glomerular ASE associated with better disease outcomes.

Science Advances · Oct 2, 2026Peer-reviewedGenomics

StACKER, A TOOL FOR SYSTEMS LEVEL ANALYSIS OF BASE STACKING IN NUCLEOTIDE-RICH STRUCTURES

Eric D. Sakkas, Daniel Krizanc, Kelly M. Thayer, Michael P. Weir

The paper introduces StACKER, a Python tool for analyzing base stacking in nucleic acid structures, and applies it to ribosome simulations to reveal conformational changes linked to translation phenotypes.

bioRxiv · Apr 13, 2025 · PreprintBioinformatics

GNN codon adjacency regulates protein translation

Joyce Sun, Pete Hwang, Eric D. Sakkas, Yancheng Zhou, Luis Perez, Ishani Dave, Jack B. Kwon, Audrey E. McMahon, Mia Wichman, Mitsu Raval, Kristen Scopino, Daniel Krizanc, Kelly M. Thayer, Michael P. Weir

The paper shows that adjacent GNN codons slow translation in yeast, likely due to ribosome interactions with the CAR surface during translocation.

bioRxiv · Mar 16, 2024 · PreprintMolecular Biology