Mitsu Raval

The paper investigates how anticodon nucleotide modifications affect translational tuning via interactions at the ribosomal CAR site.

The paper uses molecular dynamics simulations to study the interaction between the ribosome's A site and CAR site, revealing sequence-dependent modulation of hydrogen bonding and π-stacking interactions.

The paper shows that adjacent GNN codons slow translation in yeast, likely due to ribosome interactions with the CAR surface during translocation.