Placental neurosteroids shape cerebellar development and social behaviour
Claire‐Marie Vacher, Jiaqi J. O’Reilly, Jacquelyn Salzbank, Hélène Lacaille, Dana Bakalar, Sonia Sebaoui, Philippe Lière, Cheryl Clarkson Paredes, Toru Sasaki, A. G. Sathyanesan, Yuka Imamura Kawasawa, Anastas S. Popratiloff, Kazue Hashimoto‐Torii, Vittorio Gallo, Michaël Schumacher, Anna A. Penn
This study shows that placental allopregnanolone (ALLO) is critical for normal cerebellar development and social behavior in male mice, with ALLO deficiency leading to autism-like traits that can be rescued by ALLO treatment.
bioRxiv · Aug 13, 2019 · PreprintNeuroscience