Author

Jeffrey Chang

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Harvard UniversityORCID 0000-0001-9342-5072Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:protein structure· 1

Frequent Co-Authors

Nicholas F. PolizziiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

1 paper

Recent·Most cited

De novo design of small-molecule-induced conformational change

Jeffrey Chang, Nicholas F. Polizzi

This paper designs de novo proteins that undergo small-molecule-induced conformational changes, demonstrating strong binding affinity and specificity for exatecan.

bioRxiv · Aug 4, 2026 · PreprintBioengineering