PhysiologybioRxivPreprint
Spleen-dependent role of cyclooxygenase-1 in the physiological manifestations of severity in systemic inflammation
Camila F. Brito, Eduardo Hermógenes Moretti, Isis Ferraz Libório Trzan…·Alexandre A. Steiner
This study shows that COX-1 in the spleen mediates systemic inflammation severity through PGE2 and PGD2, as SC-560's effect on LPS-induced symptoms is lost after splenectomy.
DOI 10.64898/2026.07.07.737102