Yves Bigot

This study identifies PGBD5 as a transposase-derived gene essential for brain development in humans and mice, with deficiency causing intellectual disability and seizures.

This paper shows human PGBD5 can interact with four species of piggyBac-like elements and promote their chromosomal integration, similar to insect PB.

The paper investigates DNA transposition activity of PGBD5 in human cells, showing that overexpression causes DNA damage and challenges previous findings of transposition.

The paper identifies chromosomal binding targets of SETMAR isoforms in colorectal cell lines and finds isoform-specific binding to Hsmar1 ends and non-conserved sites, with differing expression profiles between cell lines and tissues.