Ezequiel Alejandro Galpern

The paper blends physics-based and inverse folding models to separate variant effects on protein stability and function, revealing distinct signatures for gain-of-function and loss-of-function variants.

The paper analyzes a large dataset of Ankyrin-containing proteins to characterize the structure, abundance, and energetics of their repetitive regions, finding that longer arrays have more similar repeats and favorable folding energy.