Sean I O’Donoghue

The paper presents a streamlined system for integrating 3D protein structures into variant analysis, enabling easy variant specification and access to structural insights.

PredictProtein provides protein sequence analysis tools, offering structure and function predictions with updates including deep learning and DNA/RNA/protein binding predictions.

The paper generates 872 structural models of SARS-CoV-2 proteins and creates a structural coverage map to help researchers understand viral mechanisms and immune disruption.

The paper introduces a method to infer temporal ordering of omics events from time series data with higher resolution than the experiment, using event maps and sparklines for visualization.