Cancer BiologyProceedings of the National Academy of SciencesPeer-reviewed
The Single-Stranded DNA-Binding Factor SUB1/PC4 Alleviates Replication Stress at Telomeres and is a Vulnerability of ALT Cancer Cells
Jean-Christophe Dubois, Erin Bonnell, A. Jordan Filion…·Alexandre Maréchal
This paper identifies SUB1 as a vulnerability in ALT cancer cells by showing it mitigates telomeric replication stress and that its depletion synergizes with replication stress-inducing therapies.
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