RASGRP4 is a key factor in KRAS activation mediated by SOS in Y1 mouse tumor cell line
Fabio Montoni, Rosangela A.M. Wailemann, Thompson E.P. Torres, Kátia Andrea de Menezes Torres, Cecilia Sella Fonseca, Marcelo S. Reis, Hugo A. Armelin
The paper develops a dynamic model of KRAS-GTP activation in Y1 cells, identifies RASGRP4 as a missing GEF, and shows its role in tumor growth.
Scientific Reports · Mar 6, 2026Peer-reviewedSystems Biology