Systems BiologyScientific ReportsPeer-reviewed
RASGRP4 is a key factor in KRAS activation mediated by SOS in Y1 mouse tumor cell line
Fabio Montoni, Rosangela A.M. Wailemann, Thompson E.P. Torres…·Hugo A. Armelin
The paper develops a dynamic model of KRAS-GTP activation in Y1 cells, identifies RASGRP4 as a missing GEF, and shows its role in tumor growth.
DOI 10.1038/s41598-026-42968-0