Marcelo S. Reis

A comprehensive temporal proteome and phosphoproteome dataset of Y1 adrenocortical cells under FGF2 stimulation and SOS inhibition

This paper generates a time-resolved proteome and phosphoproteome dataset of Y1 adrenocortical cells under FGF2 stimulation and SOS inhibition, revealing 14,512 phosphosites and 8,919 protein groups with significant changes.

RASGRP4 is a key factor in KRAS activation mediated by SOS in Y1 mouse tumor cell line

The paper develops a dynamic model of KRAS-GTP activation in Y1 cells, identifies RASGRP4 as a missing GEF, and shows its role in tumor growth.

Transcription activity contributes to the firing of non-constitutive origins in Trypanosoma brucei

The paper shows that transcription activity triggers non-constitutive origins in Trypanosoma brucei to ensure timely DNA replication.