ImmunologyMolecular TherapyPeer-reviewed
Spatiotemporal atlas of pro-inflammatory (NF-kB) and anti-inflammatory (STAT6) signalling using reporter mice during mRNA vaccination
Electra Brunialti, Alessia Panzeri, Nicoletta Rizzi…·Paolo Ciana
This paper develops a dual-reporter mouse system to analyze NF-kB and STAT6 signaling dynamics during mRNA vaccination, revealing liver as a key early hub and linking early STAT6 activation to robust humoral responses.
DOI 10.1016/j.ymthe.2026.05.028