Paolo Ciana

This study examines how nanoplastics affect microglial bioenergetics and communication with neurons in vitro, finding dose-dependent changes in ATP levels and neuroprotective signaling.

This paper develops a dual-reporter mouse system to analyze NF-kB and STAT6 signaling dynamics during mRNA vaccination, revealing liver as a key early hub and linking early STAT6 activation to robust humoral responses.

The paper introduces MyoRep, a reporter system that detects early muscle atrophy in vitro and in vivo, distinguishing pathological from physiological atrophy.

This paper identifies DNA aptamers targeting ICAM-1 to inhibit HRV infection by blocking viral entry, showing concentration-dependent antiviral effects in vitro.

This study evaluates methods for loading EGFRvIII siRNA into glioblastoma-derived extracellular vesicles, finding transfection to be the most efficient, but noting no significant tumour shrinkage in vivo.

This study shows that GCase deficiency in microglia leads to metabolic changes and ATP depletion, impairing their neuroprotective functions and increasing neuronal vulnerability in Parkinson's disease.

The paper investigates sex-specific microglial responses to glucocerebrosidase inhibition and links these responses to GBA1-linked Parkinson disease.

This study shows that inhibiting microglial GBA reduces their ability to support neuronal antioxidant responses, increasing neuronal vulnerability to toxins.