Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstream
Olivier Cabaud, Anaïs Aulas, Alexia Lopresti…·Émilie Mamessier
The paper identifies PTK7 as a marker for colorectal cancer cell plasticity and metastatic potential, showing its loss in circulating tumor cells enables stress resistance and metastasis through surfaceome remodeling.