Zhu Ning

HighFold-Lasso predicts lasso peptide structures using topology-guided methods, achieving perfect topology success and low RMSD on a test set of 52 structures.

High-PepBinder generates target-specific peptides using a pLM-guided diffusion model and a comprehensive dataset, producing peptides with favorable binding properties and sequence diversity.

The paper introduces PPIKB, a database and platform for protein-peptide interactions, compiled from literature and patents with manual validation, supporting drug discovery and systems biology research.