Wengang Zhang

mTOR variants activation discovers PI3K-like cryptic pocket, expanding allosteric, mutant-selective inhibitor designs

The paper identifies a cryptic pocket in mTOR oncogenic variants through molecular dynamics simulations and suggests designing PI3K-like inhibitors to target this pocket for therapeutic benefit.

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2

The paper investigates why cyclin-D/CDK4 drives the longer G1 phase while cyclin-E/CDK2 regulates the short G1/S transition, proposing slower activation for cyclin-D/CDK4 and faster for cyclin-E/CDK2, with implications for CDK4 inhibitor design.