This study identifies 114 novel genomic loci for anxiety and finds extensive genetic overlap with schizophrenia, bipolar disorder, major depression, and ADHD.

medRxiv · Sep 1, 2023 · PreprintGenetic & Genomic Medicine

Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.

Børge Holen, Alexey A. Shadrin, Romain Icick, Tahir Tekin Filiz, Guy Hindley, Linn Nilsen Rødevand, Kevin Sean O’Connell, Espen Hagen, Oleksandr Frei, Shahram Bahrami, Weiqiu Cheng, Nadine Parker, Markos Tesfaye, Piotr Pawel Jaholkowski, Naz Karadag, , Ole A. Andreassen

This study identifies 14 novel opioid use disorder loci and 7 shared loci with schizophrenia, bipolar disorder, and major depression using genome-wide association summary statistics.

Addiction Biology · Apr 28, 2023Peer-reviewedGenetic & Genomic Medicine

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin Sean O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Doug Bjella, Chun Chieh Fan, Torill Ueland, Srdjan Djurovic, Olav Bjerkehagen Smeland, , Ole A. Andreassen

This study uses a multivariate genetic approach to analyze personality and cognitive traits, identifying pleiotropy and improving polygenic prediction.

bioRxiv · Feb 28, 2022 · PreprintGenetics