Kevin Sean O’Connell

Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders

The paper identifies shared genetic variants between major psychiatric disorders and retinal traits, revealing molecular mechanisms linking retinal morphology to neurodevelopmental and neurotransmission processes.

Mapping genetic convergence across brain structure, mental health, and cardiometabolic disease

This study investigates genetic overlaps between psychiatric disorders, cardiometabolic diseases, and brain structure to understand shared and distinct genetic pathways contributing to comorbidity.

Leveraging the Genetics of Psychiatric Disorders to Prioritize Potential Drug Targets and Compounds

This paper uses genetic data from psychiatric disorders to prioritize drug targets and compounds, identifying genetic support for existing medications and opportunities for drug repurposing.

Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative Disorders

Bivariate GSA-MiXeR is a tool that models genetic correlations between two traits to identify genomic regions associated with psychiatric and neurodegenerative disorders using single-cell RNA sequencing data.

The shared genetic risk architecture of neurological and psychiatric disorders: a genome-wide analysis

This study analyzes GWAS data from nearly 1 million cases to show widespread genetic overlap between neurological and psychiatric disorders, with shared biological processes and divergent effect sizes.

Distinct metabolic signatures of Alzheimer's and Parkinson's disease revealed through genetic overlap with metabolic markers

This study identifies distinct genetic overlaps between Alzheimer's and Parkinson's disease and metabolic markers, revealing disease-specific pathways involving lipid metabolism and synaptic processes.

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders

The paper identifies five genomic factors explaining most genetic variance across 14 psychiatric disorders and finds shared and disorder-specific genetic signals with distinct biological functions.

Unraveling the shared genetics of common epilepsies and general cognitive ability.

This study identifies shared genetic loci between common epilepsies and general cognitive ability using LDSC, MiXeR, and conjFDR analyses.

Genome-wide meta-analyses of non-response to antidepressants identify novel loci and potential drugs

This study identifies two novel genomic loci associated with antidepressant non-response and suggests potential drugs for further validation.

Genomic Insights into the Shared and Distinct Genetic Architecture of Cognitive Function and Schizophrenia

This study identifies shared and distinct genetic factors between cognitive traits and schizophrenia using genomic structural equation modelling and GWAS data.

Dissecting the genetic overlap between three complex phenotypes with trivariate MiXeR

The paper introduces trivariate MiXeR to quantify genetic overlap between three complex phenotypes using GWAS summary statistics, demonstrating its ability to detect complex patterns of genetic overlap.

Sourcing Bivariate Genetic Overlap for Polygenic Prediction using MiXeR-Pred

MiXeR-Pred improves polygenic prediction by leveraging genetic overlap between complex phenotypes, outperforming primary GWAS and MTAG approaches.

Regional Genetic Architecture of the Corpus Callosum and its Overlap with Psychiatric and Substance Use Phenotypes

The paper investigates the genetic architecture of the corpus callosum and its overlap with psychiatric and substance use phenotypes using GWAS summary statistics and causal mixture models.

Identification of Novel Genomic Loci for Anxiety and Extensive Genetic Overlap with Psychiatric Disorders

This study identifies 114 novel genomic loci for anxiety and finds extensive genetic overlap with schizophrenia, bipolar disorder, major depression, and ADHD.

Distributed Genetic Effects of the Corpus Callosum Subregions Suggest Links to Neuropsychiatric Disorders and Related Traits

The paper identifies genetic loci associated with corpus callosum subregion volumes and finds genetic correlations with psychiatric disorders and related traits.

Unveiling the Genetic Landscape of Basal Ganglia: Implications for Common Brain Disorders

This study identifies 72 genetic loci associated with basal ganglia volumes and finds significant genetic overlaps with Parkinson's disease, schizophrenia, and migraine.

Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression.

This study identifies 14 novel opioid use disorder loci and 7 shared loci with schizophrenia, bipolar disorder, and major depression using genome-wide association summary statistics.

Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

The paper estimates bone marrow adiposity from head MRI scans and identifies its genetic architecture, revealing heritability, 41 genetic loci, and correlations with cognitive ability and Parkinson's disease.

Efficient meta-analysis of multivariate genome-wide association studies with Meta-MOSTest

The paper introduces Meta-MOSTest, an extension of MOSTest for meta-analysis of multivariate GWAS, showing it maintains statistical power and type I error control across multiple cohorts.

Genetic architecture of creativity and extensive genetic overlap with psychiatric disorders revealed from genome-wide association analyses of 241,736 individuals

This study performs a GWAS on creativity using 241,736 individuals, identifying 25 loci and showing genetic overlap with several psychiatric disorders.

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy and improves prediction

This study uses a multivariate genetic approach to analyze personality and cognitive traits, identifying pleiotropy and improving polygenic prediction.

Genetic overlap between Alzheimer's disease and depression mapped onto the brain

This study identifies genetic overlap between Alzheimer's disease and depression using GWAS data and biostatistical tools, finding shared variants and brain morphology associations.

Population-based body-brain mapping links brain morphology and body composition

This study links brain morphology and body composition using MRI data from 19,330 UK Biobank participants, finding significant associations between body measures and brain structures.

Genome-wide association study of over 40,000 bipolar disorder cases provides new insights into the underlying biology

Meta-analysis of 41,917 European-ancestry bipolar disorder cases versus 371,549 controls yields 64 risk loci (33 novel), neuronal and synaptic gene enrichment, and 15 eQTL-prioritized genes.

Association between complement component 4A expression, cognitive performance and brain imaging measures in UK Biobank

The paper investigates the association between predicted brain C4A expression and cognitive performance and brain imaging measures in the UK Biobank, finding significant negative associations and structural mediation effects.

Genome-wide association study identifies 48 common genetic variants associated with handedness.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.

The genetic architecture of human brainstem structures and their involvement in common brain disorders

The paper identifies genetic loci associated with brainstem volumes and finds genetic overlaps with psychiatric and neurological disorders.

Annotation-Informed Causal Mixture Modeling (AI-MiXeR) reveals phenotype-specific differences in polygenicity and effect size distribution across functional annotation categories

The paper introduces AI-MiXeR, a method to estimate variant counts and effect sizes across functional annotations using GWAS summary statistics, revealing phenotype-specific polygenicity and effect size differences.

Quantifying the polygenic architecture of the human cerebral cortex: Extensive genetic overlap between cortical thickness and surface area

The paper quantifies genetic overlap between cortical thickness and surface area using UK Biobank data, finding shared causal variants and suggesting more discoverable parcellation schemes.

A genome-wide genetic pleiotropy approach identified shared loci between multiple system atrophy and inflammatory bowel disease

This study identifies shared genetic loci between multiple system atrophy and inflammatory bowel disease using conjFDR, highlighting immune and gut-related molecular mechanisms.