Dishevelled drives Wnt-stimulated disassembly of primary cilia through a unique PDZ-mediated binding mode with Daple and Girdin
Miha Renko, Gonzalo J. Beitia, Trevor J. Rutherford, Mariann Bienz, Melissa V. R. Gammons
The study identifies a unique PDZ-mediated interaction between Dishevelled and Daple/Girdin-L that drives Wnt5a-induced primary cilia disassembly.
bioRxiv · Sep 26, 2025 · PreprintCell Biology