This study conducts a GWAS of Native Hawaiians and Polynesian-ancestry populations to identify population-enriched genetic associations for cardiometabolic traits, confirming some variants and highlighting the need for larger cohorts.

1 citation

humanGWAS summary statistics

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GeneticsbioRxivPreprintMay 5, 2026

Highly efficient genotype compression leveraging genealogical relatedness

Amber Z. Shen, Xinran Wang, Nicholas Mancuso, Luke Jen O’Connor

The paper introduces a lossless compression method for genotype data using genealogical relatedness, achieving significant size reduction and speedup in genetic analyses.

DOI 10.64898/2026.04.29.721594

humanwhole-genome sequencing

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MicrobiologyNature CommunicationsPeer-reviewedMay 20, 2025

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing

Wei He, Lianbei Sun, Tianyi Hou…·Lihua Xiao

The study identifies SKSR1 as a key virulence factor in Cryptosporidium by crossing isolates with different virulence and analyzing genetic loci associated with infectivity.

14 citationstop 1%

humanwhole-genome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintNov 19, 2024

Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity

Marlena S. Fejzo, Xinran Wang, Julia Zöllner…·Nicholas Mancuso

3 citations

humanGWAS summary statistics

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintApr 15, 2024

Improved multi-ancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk

Zeyun Lu, Xinran Wang, Matthew Carr…·Nicholas Mancuso

The paper introduces SuShiE, a model that improves multi-ancestry fine-mapping of cis-molQTLs, identifying more genes and prioritizing functionally enriched variants.

5 citations

humanbulk RNA-seq

𝕏 PostBluesky