Wei He

A conserved oscillatory system that positions the divisome in Archaea

This paper identifies a three-protein system in Archaea essential for divisome positioning, showing functional similarities to the bacterial Min system but with distinct sequence and mechanism.

Control of motility and cell shape of Haloferax volcanii is linked by a transcriptional regulator

This study identifies CsmR as a transcriptional regulator linking motility and cell shape in Haloferax volcanii through transcriptomic analysis and functional experiments.

Deep contrastive learning enables genome-wide virtual screening

DrugCLIP, a contrastive dense-retrieval model for pockets and molecules, beats docking on DUD-E and LIT-PCBA and screened about 10,000 human AlphaFold2 proteins in 24 hours.

Elucidating the Contribution of OVLT Glutamatergic Neurons to Mineralocorticoid Hypertension in TASK-/- Mice

The paper investigates how OVLT glutamatergic neurons contribute to hypertension in TASK-/- mice through hyperexcitability and their connections to PVN/RVLM circuits.

Targeting NOTCH2-JAG1 juxtacrine signaling reverses macrophage-mediated tumor resistance to taxol

This study identifies NOTCH2-JAG1 juxtacrine signaling as a target to reverse macrophage-mediated taxane resistance in ovarian cancer by sensitizing tumors to paclitaxel.

Residual Partial Least Squares Learning: Brain Cortical Thickness Simultaneously Predicts Eight Non-pairwise-correlated Behavioural and Disease Outcomes in Alzheimer's Disease

This paper introduces re-PLS Learning to predict multiple AD outcomes from brain cortical thickness, identifying joint predictive regions across cohorts.

The crossover function of MutSγ is activated via Cdc7-dependent stabilization of Msh4

This study shows that MutSγ activation during meiosis depends on Cdc7-mediated phosphorylation of Msh4, stabilizing the complex and enabling crossover formation.