Ronald Yurko

CWAS-Plus: Estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data

CWAS-Plus identifies noncoding variant associations in whole-genome sequencing data using cell-type-specific functional data, finding links to autism and Alzheimer's disease.

An approach to gene-based testing accounting for dependence of tests among nearby genes

This paper introduces a gene-based testing method that accounts for correlation between nearby genes in GWAS, improving power for detecting weak signals in autism spectrum disorder.

H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives

The paper critiques H-MAGMA's statistical foundation, showing many of its findings for psychiatric disorders do not replicate when methodological flaws are addressed.

A selective inference approach for FDR control using multi-omics covariates yields insights into disease risk

The paper applies adaptive p-value thresholding with multi-omics covariates to improve power in GWAS for schizophrenia while controlling FDR.