Max G’Sell

Evaluating and Improving Health Equity and Fairness of Polygenic Scores

This paper improves the portability and fairness of polygenic scores by introducing Joint-Lassosum, which outperforms existing methods in diverse ancestries.

An approach to gene-based testing accounting for dependence of tests among nearby genes

This paper introduces a gene-based testing method that accounts for correlation between nearby genes in GWAS, improving power for detecting weak signals in autism spectrum disorder.

H-MAGMA, inheriting a shaky statistical foundation, yields excess false positives

The paper critiques H-MAGMA's statistical foundation, showing many of its findings for psychiatric disorders do not replicate when methodological flaws are addressed.

Endogenous activity modulates stimulus and circuit-specific neural tuning and perception

The paper shows endogenous neural activity modulates neural tuning and perception in a circuit- and stimulus-specific manner using intracranial recordings from epilepsy patients.

A selective inference approach for FDR control using multi-omics covariates yields insights into disease risk

The paper applies adaptive p-value thresholding with multi-omics covariates to improve power in GWAS for schizophrenia while controlling FDR.

Shrinkage Classification for Overlapping Time Series: An interpretable method for mapping stimulus-differentiated evoked response

SCOTS maps brain function from neural time series by integrating spatio-temporal dependence through dimensionality reduction and classification, revealing category-specific neural activation patterns.

Architecture of a multi-cellular polygenic network governing immune homeostasis

The paper identifies a polygenic network governing immune homeostasis using mass-cytometry data from 55 mouse strains, showing 52% of trait genes predict phenotype and revealing multi-cellular regulatory complexity.