Chanhee Kim

The paper develops simCRISPR, a simulation framework for pooled CRISPR screens, evaluates normalization strategies for detecting gene-by-environment interactions, and shows improved results with safe-harbor normalization.

This paper develops a 3D CRISPR screening system using HepG2/C3A spheroids to improve the identification of genetic determinants of chemical toxicity compared to traditional 2D methods.

This study identifies 340 genes modulating PFOS-induced cytotoxicity in liver cells using CRISPR screens and validates two genes, SLC6A9 and CPSF2, with functional and molecular evidence.

The paper identifies C18orf32 as a novel regulator of lipid metabolism involved in PFOA-induced toxicity through CRISPR screening and transcriptomic analysis.

CWAS-Plus identifies noncoding variant associations in whole-genome sequencing data using cell-type-specific functional data, finding links to autism and Alzheimer's disease.

The paper identifies an osmolality-responsive enhancer in tilapia that regulates glutamine synthetase expression under hyperosmotic conditions.