Feedstock-Efficient Conversion through Hydrogen and Formate-Driven Metabolism in Escherichia coli
Robert L. Bertrand, Justin Panich, Aidan E. Cowan, Jacob B. Roberts, Lesley J. Rodriguez, Juliana Artier, Emili Toppari, Edward E. K. Baidoo, Yan Chen, Christopher J. Petzold, Graham A. Hudson, Patrick M. Shih, Steven W. Singer, Jay D. Keasling
This paper engineers Escherichia coli to use hydrogen and formate as energy sources, improving mevalonate production by 57.6% through metabolic decoupling.
Metabolic Engineering · Oct 15, 2025Peer-reviewedSynthetic Biology