Author
Worcester Polytechnic InstituteORCID 0000-0001-9737-5084Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Hongzhu Cui, Suhas Srinivasan, Ziyang Gao, Dmitry Korkin
The paper analyzes population-specific mutations' impact on the human interactome using in-silico edgetic profiling of nsSNVs from the 1,000 Genomes Project.
Zhong Ren, Gundula Povysil, Joseph A. Hostyk…·David B. Goldstein
ATAV provides a scalable platform for population-scale genomic analyses, enabling efficient variant storage, querying, and disease association studies with over 110,000 samples.
Hongzhu Cui, Ziyang Gao, Ming Liu…·Dmitry Korkin
The paper uses computational methods to analyze structural genomics and interactomics of 2019-nCoV, comparing it to SARS coronavirus to identify conserved functional regions.
Hongzhu Cui, Chong Zhou, Xinyu Dai…·Dmitry Korkin
This paper introduces a deep learning-based clustering method for gene expression data that integrates biological information, outperforming existing methods on yeast and human datasets.
Hongzhu Cui, Suhas Srinivasan, Dmitry Korkin
The paper introduces DIMSUM, a computational framework that integrates GWAS, mutation effects, and PPI networks to detect disease-specific modules in the human interactome, showing improved biological relevance and disease association.
Hongzhu Cui, Nan Zhao, Dmitry Korkin
This study characterizes pathogenic SNVs and frameshift mutations by analyzing their edgetic effects on the human interactome, revealing differences in pleiotropy and interaction disruption.