Silvia De Santis

This paper integrates longitudinal neuroimaging and microbiota data in rats to identify Akkermansia as a microbial modulator of alcohol-induced gut-liver-brain pathology and validates its therapeutic potential.

This study uses longitudinal MRI and complementary techniques in rats to show that female-specific brain connectivity and white matter preservation support cognitive resilience with age, mediated by sex hormones.

This paper introduces a simulation-based inference method for diffusion MRI that reduces scan time and improves accuracy with minimal data.

The paper develops a mouse MRI atlas with both sexes included to address sex bias in preclinical research and demonstrates its utility in integrating imaging and molecular data.

SAMson is an automated tool for rodent brain extraction from MRI data, outperforming existing methods in segmentation accuracy across diverse datasets.

The paper validates an MRI framework for detecting axonal damage in rats and humans, showing increased axonal caliber in both pathological and normal-appearing white matter in multiple sclerosis patients.

This study shows sleep loss impairs myelin function by disrupting cholesterol metabolism in oligodendrocytes, leading to conduction delays and motor deficits.

This paper introduces a non-invasive diffusion MRI method to image microglia and astrocyte activation in vivo, showing it can detect glia proliferation and correlate with histological markers in humans.