Santiago Canals

This paper integrates longitudinal neuroimaging and microbiota data in rats to identify Akkermansia as a microbial modulator of alcohol-induced gut-liver-brain pathology and validates its therapeutic potential.

This study uses longitudinal MRI and complementary techniques in rats to show that female-specific brain connectivity and white matter preservation support cognitive resilience with age, mediated by sex hormones.

This study shows that PV+ interneurons in the dentate gyrus regulate the balance between sensitivity and consistency in memory formation by shifting hippocampal computation.

This study shows that NAc-DBS enhances long-term memory encoding without affecting memory recall or working memory in rats.

This paper develops a computational model showing that feedforward and feedback inhibition modulate theta-gamma cross-frequency interactions in a bidirectional manner, with directionality dependent on synaptic strength and circuit structure.

The paper investigates decision making under intermittent information streams with temporal gaps, finding that participants disproportionately weight post-gap information, which traditional models cannot explain.

SAMson is an automated tool for rodent brain extraction from MRI data, outperforming existing methods in segmentation accuracy across diverse datasets.

The paper shows that reducing inhibition in the dentate gyrus during learning enhances information processing and pattern separation through synaptic plasticity and computational modeling.

This paper introduces a non-invasive diffusion MRI method to image microglia and astrocyte activation in vivo, showing it can detect glia proliferation and correlate with histological markers in humans.

The paper identifies and characterizes distinct theta current generators in the hippocampus and shows their coordinated activity during memory-guided exploration and novelty detection.

The paper identifies a role for PV interneurons in the dentate gyrus in coordinating brain-wide communication and memory updating through polysynaptic networks.